Dr Michael Carty

Research Interests

  • DNA damage response pathways in human mesenchymal stem cells and normal primary melanocytes
  • Mechanistic investigation of the cellular response to DNA damage-induced replication arrest

Dr Elaine Dunleavy

Research Interests

  • Centromere assembly and propagation in meiosis and early development

Dr Andrew Flaus

Research Interests

  • Design principles of the nucleosome
  • Mechanism of ATP-dependent remodelling
  • Role of chromatin structure in DNA repair and in centromere function

Prof Bob Lahue

Research Interests

  • DNA mutagenesis and repair
  • Trinucleotide repeat instability

Prof Noel Lowndes

Research Interests

  • Biological responses to DNA damage in eukaryotic model systems
  • Epigenetic regulation of the DNA damage response
  • Identification and characterisation of new DDR activities

Prof Brian McStay

Research Interests

  • The organisation of ribosomal gene arrays
  • Formation of the nucleolus in human cells

Prof Ciaran Morrison

Research Interests

  • How DNA damage impacts on centrosome duplication, cohesion and ciliogenesis
  • Roles of the centrosomal/ pericentriolar material components, Pericentrin and Mcph1, in cell cycle control
  • Activities of centrosome proteins (centrin, Cep164, Cep290) in DNA repair
  • Regulation of centrosome and centriole cohesion

Prof Heinz-Peter Nasheuer

Research Interests

  • Mechanisms and regulation of human DNA replication
  • DNA damage-induced re-localization of DNA repair proteins in mitosis
  • Protein-protein interactions in living cells
  • DNA replication of human polyoma viruses

Dr Stephen Rea

Research Interests

  • Epigenetic regulation of gene expression
  • Histone modifications in normal development and disease

Prof Corrado Santocanale

Research Interests

  • Mechanisms of genome replication: function and regulation of Cdc7 kinase
  • Cancer therapeutics

Prof Kevin Sullivan

Research Interests

  • Centromere replication: epigenetic chromosome inheritance
  • Mitotic checkpoints, apoptosis and cancer chemotherapeutics
  • Quantitative microscopy and phenotypic analysis of cells