Dr Michael Carty

Research Interests

  • UV radiation- and cisplatin-induced DNA damage response pathways in human cells
  • Mechanistic investigation of the role of DNA polymerase eta in translesion synthesis
  • Characterisation of the effects of novel anti-cancer agents

Dr Elaine Dunleavy

Research Interests

  •  Centromere assembly in meiosis
  •  Centromere maintenance during spermiogenesis
  •  Germ line stem cell maintenance
  •  Epigenetics

Dr Andrew Flaus

Research Interests

  • Design principles of the nucleosome
  • Mechanism of ATP-dependent remodelling
  • Role of chromatin structure in DNA repair and in centromere function

Prof Bob Lahue

Research Interests

  • DNA mutagenesis and repair
  • Trinucleotide repeat instability

Prof Noel Lowndes

Research Interests

  • Biological responses to DNA damage in eukaryotic model systems
  • Epigenetic regulation of the DNA damage response
  • Regulation of mitotic progression
  • Functional analysis of PIK kinases

Prof Brian McStay

Research Interests

  • The organisation of ribosomal gene arrays
  • Formation of the nucleolus in human cells

Prof Ciaran Morrison

Research Interests

  • How DNA damage affects centrosomes and cilia
  • Roles of the pericentriolar material in cell cycle control
  • Activities of centrosome proteins in DNA repair
  • Cancer, cellular senescence and the centrosome

Prof Heinz-Peter Nasheuer

Research Interests

  • Mechanisms and regulation of human DNA replication
  • DNA damage-induced re-localization of DNA repair proteins in mitosis
  • Protein-protein interactions in living cells
  • DNA replication of human polyoma viruses

Dr Stephen Rea

Research Interests

  • Chromatin regulation of the DNA damage response
  • Histone modifications in normal development and disease
  • Epigenetic regulation of gene expression

Prof Corrado Santocanale

Research Interests

  • Mechanisms of genome duplication
  • Cancer therapeutics

Prof Kevin Sullivan

Research Interests

  • Centromere replication: epigenetic chromosome inheritance
  • Mitotic checkpoints, apoptosis and cancer chemotherapeutics
  • Quantitative microscopy and phenotypic analysis of cells