Research Interests
- UV radiation- and cisplatin-induced DNA damage response pathways in human cells
- Mechanistic investigation of the role of DNA polymerase eta in translesion synthesis
- Characterisation of the effects of novel anti-cancer agents
Research Interests
- Centromeres
- Epigenetics
- Meiosis
- Germline stem cells
Research Interests
- Design principles of the nucleosome
- Mechanism of ATP-dependent remodelling
- Role of chromatin structure in DNA repair and in centromere function
Research Interests
- Developmental biology
- Stem cell biology
- Regeneration biology
Research Interests
- DNA mutagenesis and repair
- Trinucleotide repeat instability
Research Interests
- Biological responses to DNA damage in eukaryotic model systems
- Epigenetic regulation of the DNA damage response
- Regulation of mitotic progression
- Functional analysis of PIK kinases
Research Interests
- The organisation of ribosomal genes on human acrocentric chromosomes
- Formation and organisation of the nucleolus in human cells
Research Interests
- How DNA damage affects centrosomes and cilia
- Roles of the pericentriolar material in cell cycle control
- Activities of centrosome proteins in DNA repair
- Cancer, cellular senescence and the centrosome
Research Interests
- Mechanisms and regulation of human DNA replication
- DNA damage-induced re-localization of DNA repair proteins in mitosis
- Protein-protein interactions in living cells
- DNA replication of human polyoma viruses
Research Interests
- Chromatin regulation of the DNA damage response
- Histone modifications in normal development and disease
- Epigenetic regulation of gene expression
Research Interests
- Mechanisms of genome replication: function and regulation of Cdc7 kinase
- Cancer therapeutics
Research Interests
- Centromere replication: epigenetic chromosome inheritance
- Mitotic checkpoints, apoptosis and cancer chemotherapeutics
- Quantitative microscopy and phenotypic analysis of cells
